| 段秀凤,王文亮,王兰,郑昕怡,程进宝,李新平.玉米醇溶蛋白/羧甲基纤维素/果胶复合纳米颗粒稳定Pickering乳液及其递送行为研究[J].中国造纸,2026,45(10):199-205 |
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| 玉米醇溶蛋白/羧甲基纤维素/果胶复合纳米颗粒稳定Pickering乳液及其递送行为研究 |
| Research of Zein/CMC/Pectin Composite Nanoparticle-stabilized Pickering Emulsion and Its Delivery Behavior |
| 收稿日期：2026-03-20 修订日期：2026-04-07 |
| DOI：10.11980/j.issn.0254-508X.2026.10.021 |
| 关键词: 玉米醇溶蛋白 羧甲基纤维素 果胶 Pickering乳液 EGCG |
| Key Words:Zein carboxymethyl cellulose pectin Pickering emulsion EGCG |
| 基金项目:国家自然科学基金 32571992国家自然科学基金（32571992）。 |
| 作者 | 单位 | 邮编 | | 段秀凤* | 陕西科技大学轻工科学与工程学院,陕西西安,710021 | 710021 | | 王文亮* | 陕西科技大学轻工科学与工程学院,陕西西安,710021 | 710021 | | 王兰 | 陕西科技大学轻工科学与工程学院,陕西西安,710021 | 710021 | | 郑昕怡 | 陕西科技大学轻工科学与工程学院,陕西西安,710021 | 710021 | | 程进宝 | 陕西科技大学轻工科学与工程学院,陕西西安,710021 | 710021 | | 李新平 | 陕西科技大学轻工科学与工程学院,陕西西安,710021 | 710021 |
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| 摘要:本研究以玉米醇溶蛋白（Zein）、羧甲基纤维素（CMC）和果胶（Pec）为原料，构建复合纳米颗粒并将其作为稳定剂制备水包油型Pickering乳液，探讨了二元及三元复合体系对乳液稳定性的影响及其递送表没食子儿茶素没食子酸酯（EGCG）在模拟胃肠消化条件下的释放行为。结果表明，引入CMC和Pec可改善Zein纳米颗粒的分散稳定性，当Zein与CMC质量比为1∶1时，复合纳米颗粒Zein/CMC/Pec的形貌最规整，由其稳定的Pickering乳液液滴粒径最小且界面吸附结构最稳定，有效调控了颗粒表面的亲水-疏水平衡。体外模拟消化实验结果显示，该Pickering乳液在胃消化阶段能有效抑制EGCG突释；在肠消化阶段，Pickering乳液对EGCG的保留率稳定在54%~59%的高位区间，而游离EGCG对照组肠阶段保留率骤降至约8%。该Pickering乳液具备优良的结构稳定性与pH响应阶段性缓释特征，能够为多酚类功能因子的稳态化递送提供有效载体策略。 |
| Abstract:In this study， composite nanoparticles were fabricated using Zein， carboxymethyl cellulose (CMC), and pectin (Pec) as raw materials to stabilize oil-in-water Pickering emulsions. The effects of binary and ternary composite systems on emulsion stability and their delivery behavior of epigallocatechin gallate (EGCG) under simulated gastrointestinal digestion were systematically investigated. The results demonstrated that the incorporation of CMC and Pec significantly enhanced the dispersion stability of zein nanoparticles. Specifically, at the optimal mass ratio of zein to CMC of 1∶1, the nanoparticles Zein/CMC/Pec exhibited the most uniform morphology. The Pickering emulsion stability by these nanopartides smallest droplet size and the most stable interfacial adsorption structure, effectively modulating the hydrophilic-hydrophobic balance. The results of in vitro simulated digestion revealed that the Pickering emulsion effectively suppressed the burst release of EGCG in the gastric phase. Notably, during the intestinal phase, the EGCG retention rate in the Pickering emulsion remained stable at a high level of 54%~59%, whereas that of free EGCG plummeted to approximately 8%. This Pickering emulsion possesses superior structural stability and pH-responsive staged release characteristics, offering a promising carrier strategy for the stable delivery of polyphenolic functional factors. |
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